[Dyspeptic syndrome associated with antidiabetic therapy].

Abstract

Dyspeptic syndrome is a common complication of treatment with antidiabetic drugs. This may be a trivial as well as a very serious complication. Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite and taste disturbances are the most common symptoms of dyspeptic problems in patients treated with metformin. They rarely are a reason for treatment discontinuation. Dyspeptic syndrome is a common complication in patients treated with acarbose, this may be prevented by reduced intake of sucrose. Pneumatosis cystoides intestinalis is a rare complication in acarbose-treated patients. Antiobesity agent orlistat is frequently associated with dyspeptic symptoms, particularly if fat intake is not reduced. Treatment with drugs affecting the incretin system (dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists) is very rarely complicated by acute pancreatitis. Glucagon-like peptide-1 receptor agonists may cause dyspeptic symptoms (nausea, vomiting, diarrhoea) at the beginning of treatment. These complaints usually cease and the treatment usually does not need to be discontinued.

• Authors: A Smahelová
• Journal: Vnitrni lekarstvi (Vnitr Lek) Vol. 57 Issue 4 Pg. 391-5 (Apr 2011) ISSN: 0042-773X [Print] Czech Republic
• Vernacular Title: Dyspeptický syndrom pri antidiabetické lécbe.
• PMID: 21612066 (Publication Type: Journal Article, Review)

Chemical References

• Hypoglycemic Agents
• Lactones
• Metformin
• Orlistat
• Acarbose

Topics

• Acarbose (adverse effects)
• Dyspepsia (chemically induced)
• Humans
• Hypoglycemic Agents (adverse effects)
• Lactones (adverse effects)
• Metformin (adverse effects)
• Orlistat