Abstract | CONTEXT: OBJECTIVE: Our objective was to study the relationship between OPG concentration and bone microarchitecture in men. DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional study of a population-based cohort of 1149 men aged 20-87 yr. INTERVENTIONS: MAIN OUTCOME MEASURES: Differences were assessed in bone microarchitectural parameters across the OPG quartiles in the models adjusted for age, weight, height, physical activity, ischemic heart disease, diabetes mellitus, calcium intake, serum levels of free testosterone, bioavailable 17β-estradiol, PTH, 25-hydroxycholecalciferol, and creatinine. RESULTS: After adjustment for the confounders, men in the highest (fourth) quartile of OPG levels (>4.55 pmol/liter) had higher total cross-sectional area and trabecular area at the distal radius and distal tibia (3.3-6.0%, P < 0.05). At both skeletal sites, the highest OPG quartile was associated with lower cortical thickness (8.2%, P < 0.001, and 3.7%, P < 0.05) and volumetric bone mineral density (vBMD, 2.7%, P < 0.001, and 1.6%, P < 0.005) compared with the three lower quartiles combined. Associations of OPG level with trabecular vBMD, number, thickness, and distribution were not significant. Men in the fourth OPG quartile had higher levels of bone resorption markers (11.8-13.1%, P < 0.01-0.001). CONCLUSIONS: Men with higher serum OPG concentration had lower cortical thickness and vBMD, probably due to accelerated endo- and intracortical bone turnover, but higher cross-sectional area possibly due to periosteal apposition.
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Authors | P Szulc, G Hawa, S Boutroy, N Vilayphiou, M Schoppet, R Chapurlat, L C Hofbauer |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 96
Issue 7
Pg. 2216-26
(Jul 2011)
ISSN: 1945-7197 [Electronic] United States |
PMID | 21565793
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Osteoprotegerin
- Testosterone
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bone Density
(physiology)
- Bone and Bones
(physiology)
- Cross-Sectional Studies
- Humans
- Male
- Middle Aged
- Osteoprotegerin
(blood)
- Prospective Studies
- Testosterone
(blood)
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