Abstract | BACKGROUND: METHODS: We performed a single-arm, open-label, fixed- drug dosage, prospective study (NCT00699478) involving gastric cancer patients who underwent total gastrectomy. Vitamin B12-deficient (<200 pg/ml) patients ( n = 30) received daily oral vitamin B12 (dosage: 1500 μg mecobalamin) administration for 3 months. The primary outcome measurement was serum vitamin B12. The secondary outcome measurements were improvement of neurologic symptoms and hematologic findings (serum folate, homocysteine, ferritin, iron, total iron binding capacity, transferrin, and mean corpuscular volume). For comparison, another group of vitamin B12 deficient patients ( n = 30) received intramuscular vitamin B12 injections (dosage: 1000 μg cyanocobalamin) weekly for 5 weeks and monthly thereafter for a total of 3 months in a separate study period. RESULTS: CONCLUSIONS:
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Authors | Hyoung-Il Kim, Woo Jin Hyung, Ki Jun Song, Seung Ho Choi, Choong-Bai Kim, Sung Hoon Noh |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 18
Issue 13
Pg. 3711-7
(Dec 2011)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21556950
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Biological Availability
- Female
- Follow-Up Studies
- Gastrectomy
(adverse effects)
- Humans
- Male
- Middle Aged
- Postoperative Complications
- Prognosis
- Prospective Studies
- Stomach Neoplasms
(complications, surgery)
- Vitamin B 12
(administration & dosage, analogs & derivatives)
- Vitamin B 12 Deficiency
(drug therapy, etiology)
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