Abstract |
We have retrospectively investigated 15 nasopharyngeal carcinoma patients treated at our institution between March 2007 and August 2009. We used simultaneous integrated-boost whole field intensity-modulated radiation therapy (SIB WF-IMRT) to treat the entire planning target volume in the head and neck cancer. All of the SIB WF-IMRT plans were replanned by use of the junctioned intensity modulated radiation therapy (J-IMRT) technique for comparison. The effect on target coverage and sparing of organs at risk, including laryngeal sparing in the optimal SIB WF-IMRT plan was compared with that achieved with use of the J-IMRT technique. The mean larynx dose and standard deviation was 25.2 ± 5.8 Gy for SIB WF-IMRT and 19.8 ± 16.8 Gy for J-IMRT. A comparison between SIB WF-IMRT and the J-IMRT technique demonstrated that the larynx dose was increased in SIB WF-IMRT. However, when the strong dose constraint was applied to the larynx and the pseudo-volume was used for a steep dose fall-off immediately outside the target, the SIB WF-IMRT technique would have led to a larynx dose comparable to that achieved with J-IMRT. Therefore, in our current practice we use the SIB WF-IMRT technique, which does not have the problem of setup error at the match line for treatment of nasopharyngeal carcinoma.
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Authors | Jin-Beom Chung, Jeong-Woo Lee, Jae-Sung Kim, In-Ah Kim, Doo-Hyun Lee, Yon-Lae Kim, Kyoung-Sik Choi, Bo-Young Choe, Tae-Suk Suh |
Journal | Radiological physics and technology
(Radiol Phys Technol)
Vol. 4
Issue 2
Pg. 180-4
(Jul 2011)
ISSN: 1865-0341 [Electronic] Japan |
PMID | 21556851
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Brain Stem
(radiation effects)
- Carcinoma
- Eye
(radiation effects)
- Female
- Humans
- Larynx
(radiation effects)
- Male
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms
(pathology, radiotherapy)
- Optic Chiasm
(radiation effects)
- Optic Nerve
(radiation effects)
- Organs at Risk
- Parotid Gland
(radiation effects)
- Pharynx
(radiation effects)
- Radiotherapy Dosage
- Radiotherapy, Intensity-Modulated
(methods, standards)
- Spinal Cord
(radiation effects)
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