A high-sucrose diet induces fatty liver, but not deterioration of diabetes mellitus in Zucker diabetic fatty rats.

Abstract

A high-sucrose diet induces insulin resistance and dyslipidemia in normal rats. The purpose of the present study was to investigate effects of a high-sucrose diet to glycolipid metabolism in Zucker Diabetic Fatty (ZDF) rat. Male ZDF rats were fed with a high-sucrose (68%) diet from 6 to 18 weeks of age. In biochemical analyses, the glucose levels did not change as compared with those in standard diet-fed rats, but the total cholesterol levels were elevated during the experimental period. In pathological analyses, the relative liver weight increased by about 2-fold as compared with that in standard diet-fed rats, and severe fatty change was observed by high-sucrose feeding. A high-sucrose diet induces fatty liver, but not deterioration of diabetes mellitus in ZDF rats. High sucrose-fed rats are considered to be very useful to determine the relationship between hepatic insulin resistance and diabetes mellitus.

• Authors: Takeshi Ohta, Katsuhiro Miyajima, Takahisa Yamada
• Journal: Research communications in molecular pathology and pharmacology (Res Commun Mol Pathol Pharmacol) 2007-2008 Vol. 120-121 Issue 1-6 Pg. 55-64 ISSN: 1078-0297 [Print] United States
• PMID: 21469504 (Publication Type: Journal Article)

Chemical References

• Dietary Sucrose
• Glycolipids
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Diabetes Mellitus, Experimental (etiology, metabolism)
• Dietary Sucrose (administration & dosage, adverse effects)
• Disease Models, Animal
• Dyslipidemias (etiology, metabolism)
• Fatty Liver (etiology, metabolism, pathology)
• Glycolipids (metabolism)
• Insulin Resistance
• Male
• Organ Size
• Rats
• Rats, Zucker