Combination antifungal therapy for disseminated fusariosis in immunocompromised patients : a case report and literature review.

Abstract	Fusarium species are the second leading cause of disseminated mold infections in immunocompromised patients. The high mortality caused by such infections is attributed to the high resistance of Fusarium species to current antifungal agents. We report the first case of disseminated fusariosis after the use of alemtuzumab, an anti-CD52 monoclonal antibody, in a patient who presented with striking cutaneous and oral cavity lesions. Case reports of combination antifungal therapy for disseminated fusariosis in immunocompromised patients were reviewed. Among 19 published cases in the last 10 years plus this patient, the patients in 14 cases (70%) responded positively to combination antifungal therapy. A clinical response was achieved in seven cases before resolution of neutropenia.
Authors	Jyh-You Liu, Wei-Ting Chen, Bor-Sheng Ko, Ming Yao, Po-Ren Hsueh, Cheng-Hsiang Hsiao, Yu-Min Kuo, Yee-Chun Chen
Journal	Medical mycology (Med Mycol) Vol. 49 Issue 8 Pg. 872-8 (Nov 2011) ISSN: 1460-2709 [Electronic] England
PMID	21449694 (Publication Type: Case Reports, Journal Article, Review)
Chemical References	Antibodies, Monoclonal, Humanized Antifungal Agents Antineoplastic Agents Drug Combinations Pyrimidines Triazoles Deoxycholic Acid Alemtuzumab Amphotericin B amphotericin B, deoxycholate drug combination Voriconazole
Topics	Adult Alemtuzumab Amphotericin B (pharmacology, therapeutic use) Antibodies, Monoclonal, Humanized (adverse effects, therapeutic use) Antifungal Agents (pharmacology, therapeutic use) Antineoplastic Agents (adverse effects, therapeutic use) Combined Modality Therapy Deoxycholic Acid (pharmacology, therapeutic use) Drug Combinations Drug Therapy, Combination Fever Fusariosis (diagnosis, microbiology, therapy) Fusarium (cytology, drug effects, isolation & purification) Granulocytes Humans Immunocompromised Host Leukocyte Transfusion Lymphoma, T-Cell, Cutaneous (complications, drug therapy) Male Microbial Sensitivity Tests Neutropenia Pyrimidines (pharmacology, therapeutic use) Skin Neoplasms (complications, drug therapy) Triazoles (pharmacology, therapeutic use) Voriconazole

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