A new method using MRI to delineate areas of head and neck cancer targeted by intra-arterial infusion via a superficial temporal artery.

Abstract

To determine whether anticancer drugs delivered via arterial infusion can permeate entire tumors using a new MRI flow check method. We infused 20 ml of contrast medium (2 ml of Gd-GDPA plus 18 ml of normal saline) over a period of 10 min using a continuous injection pump, then immediately performed MRI using a 1.5 T unit. Images were obtained in 5-mm-thick continuous sections in two or three planes (axial, coronal, and sagittal) depending on the extent of the tumor, and enhanced fast gradient echo 3 D (EFGRE3D) images with a special inversion at lipids were photographed using a neurovascular array coil. The new MRI flow check method delineated an area of tongue cancer perfused with drugs more accurately than conventional methods.The MRI flow check method provides accurate information about areas of arterial infusion.

• Authors: Tatsuya Nakamura, Nobukazu Fuwa, Kanako Takayama, Takuya Tomoda, Akinori Takada, Chiyoko Makita, Miho Shiomi, Jun-ichi Yokouchi, Kazuo Watanabe
• Journal: Oral oncology (Oral Oncol) Vol. 47 Issue 5 Pg. 387-90 (May 2011) ISSN: 1879-0593 [Electronic] England
• PMID: 21444237 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Contrast Media

Topics

• Adult
• Antineoplastic Agents (administration & dosage, pharmacokinetics)
• Carcinoma, Squamous Cell (drug therapy, metabolism)
• Contrast Media
• Female
• Head and Neck Neoplasms (drug therapy, metabolism)
• Humans
• Infusions, Intra-Arterial (methods)
• Magnetic Resonance Imaging, Interventional (methods)
• Temporal Arteries
• Tongue Neoplasms (drug therapy, metabolism)
• Treatment Outcome