Abstract | OBJECTIVES: An experimental study was performed to evaluate both in vitro and in vivo the efficacy of clarithromycin coating combined with systemic amikacin in preventing ureteral stent biofilm infection due to Pseudomonas aeruginosa. METHODS: RESULTS: The in vitro studies showed that the biofilm was strongly affected by the presence of clarithromycin and, in its presence, amikacin had MICs and MBCs lower than those obtained in the absence of clarithromycin. For the singly treated groups, intraperitoneal amikacin showed the strongest effect on bacterial numbers. A clarithromycin coating combined with systemic amikacin showed an efficacy that was higher than that of each single compound. CONCLUSIONS:
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Authors | Oscar Cirioni, Roberto Ghiselli, Carmela Silvestri, Daniele Minardi, Eleonora Gabrielli, Fiorenza Orlando, Massimiliano Rimini, Lucia Brescini, Giovanni Muzzonigro, Mario Guerrieri, Andrea Giacometti |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 66
Issue 6
Pg. 1318-23
(Jun 2011)
ISSN: 1460-2091 [Electronic] England |
PMID | 21406436
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Coated Materials, Biocompatible
- Amikacin
- Clarithromycin
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Topics |
- Amikacin
(pharmacology)
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Biofilms
(drug effects, growth & development)
- Clarithromycin
(pharmacology)
- Coated Materials, Biocompatible
- Disease Models, Animal
- Drug Synergism
- Drug Therapy, Combination
(methods)
- Female
- Pseudomonas Infections
(microbiology, prevention & control)
- Pseudomonas aeruginosa
(drug effects, growth & development)
- Rats
- Rats, Wistar
- Stents
(microbiology)
- Ureteral Diseases
(microbiology, prevention & control)
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