Abstract | BACKGROUND: Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin's lymphoma. However, little is known regarding epigenetic similarities between cells of classical Hodgkin's lymphoma and plasma cell myeloma, both of which share extinction of the gene expression program of mature B cells. DESIGN AND METHODS: RESULTS: CONCLUSIONS: Our epigenetic data support the view that classical Hodgkin's lymphoma is characterized by abortive plasma cell differentiation with a down-regulation of characteristic B-cell genes but without activation of most genes typical of plasma cells.
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Authors | Volkhard Seitz, Philippe E Thomas, Karin Zimmermann, Ulrike Paul, Anke Ehlers, Maria Joosten, Lora Dimitrova, Dido Lenze, Anke Sommerfeld, Elisabeth Oker, Ulf Leser, Harald Stein, Michael Hummel |
Journal | Haematologica
(Haematologica)
Vol. 96
Issue 6
Pg. 863-70
(Jun 2011)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 21393330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Histone Deacetylase Inhibitors
- Histones
- Hydroxamic Acids
- Polycomb-Group Proteins
- Repressor Proteins
- Deoxycytidine
- trichostatin A
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Topics |
- Acetylation
(drug effects)
- Cell Differentiation
- Cell Line, Tumor
- DNA Methylation
(drug effects)
- Deoxycytidine
(pharmacology)
- Epigenesis, Genetic
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
(drug effects)
- Histone Deacetylase Inhibitors
(pharmacology)
- Histones
(metabolism)
- Hodgkin Disease
(genetics, metabolism, pathology)
- Humans
- Hydroxamic Acids
(pharmacology)
- Plasma Cells
(cytology, pathology)
- Polycomb-Group Proteins
- Promoter Regions, Genetic
(genetics)
- Repressor Proteins
(metabolism)
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