Abstract | OBJECTIVES: METHODS: We searched MEDLINE and EMBASE for clinical studies that included CSF lactate measurement in bacterial meningitis and aseptic meningitis. Test characteristics were pooled using hierarchical summary ROC curve and random effects model. RESULTS: Thirty three studies were included. The pooled test characteristics of CSF lactate were sensitivity 0.93 (95% CI: 0.89-0.96), specificity 0.96 (95% CI: 0.93-0.98), likelihood ratio positive 22.9 (95% CI: 12.6-41.9), likelihood ratio negative 0.07 (95% CI: 0.05-0.12), and diagnostic odds ratio 313 (95% CI: 141-698). Pretreatment with antibiotics lowered the sensitivity 0.49 (95% CI: 0.23-0.75). CSF lactate of around 35 mg/dl (34-36 mg/dl) had higher sensitivity and specificity than those of around 27 mg/dl (26-28 mg/dl). CONCLUSIONS:
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Authors | Ken Sakushima, Yasuaki Hayashino, Takehiko Kawaguchi, Jeffrey L Jackson, Shunichi Fukuhara |
Journal | The Journal of infection
(J Infect)
Vol. 62
Issue 4
Pg. 255-62
(Apr 2011)
ISSN: 1532-2742 [Electronic] England |
PMID | 21382412
(Publication Type: Journal Article, Meta-Analysis, Review)
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Copyright | Copyright © 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Diagnosis, Differential
- Humans
- Lactic Acid
(cerebrospinal fluid)
- Meningitis, Aseptic
(cerebrospinal fluid, diagnosis)
- Meningitis, Bacterial
(cerebrospinal fluid, diagnosis)
- Predictive Value of Tests
- Reproducibility of Results
- Sensitivity and Specificity
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