[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].

Abstract

The activity of detoxication enzymes in liver microsomal fraction of preliminary radiation-exposed rats was investigated. It was shown that preliminary organism exposure to radiation reduced cytochrome P450 and glutathione-S-transferase activity in liver microsomal fraction in the latent and logarithmic phases of oncogenesis compared with the unirradiated rats with tumor. Low level of cytochrome P450 activity can be caused by transition of microsomal cytochrome P450 in P420 inactive form. The preliminary radiation does not influence the enzyme activity of liver cytochrome P450 and glutathione-S-transferase on terminal stages of Guerin's carcinoma growth.

• Authors: M M Marchenko, G P Kopyl'chuk, O V Ketsa
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2010 Mar-Apr Vol. 56 Issue 2 Pg. 266-73 ISSN: 2310-6972 [Print] Russia (Federation)
• PMID: 21341514 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytochrome P-450 Enzyme System
• Glutathione Transferase

Topics

• Animals
• Cytochrome P-450 Enzyme System (metabolism)
• Female
• Glutathione Transferase (metabolism)
• Liver (metabolism, radiation effects)
• Microsomes, Liver (enzymology, radiation effects)
• Neoplasm Transplantation
• Neoplasms, Experimental (enzymology)
• Rats
• Time Factors