Antimony toxicity.

Abstract

Antimony toxicity occurs either due to occupational exposure or during therapy. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. In addition antimony trioxide is possibly carcinogenic to humans. Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. As a therapeutic, antimony has been mostly used for the treatment of leishmaniasis and schistosomiasis. The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections. Quality control of each batch of drugs produced and regular monitoring for toxicity is required when antimonials are used therapeutically.

• Authors: Shyam Sundar, Jaya Chakravarty
• Journal: International journal of environmental research and public health (Int J Environ Res Public Health) Vol. 7 Issue 12 Pg. 4267-77 (12 2010) ISSN: 1660-4601 [Electronic] Switzerland
• PMID: 21318007 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Antimony
• antimony trioxide

Topics

• Antimony (therapeutic use, toxicity)
• HIV Infections (drug therapy)
• Heart (drug effects)
• Humans
• Leishmaniasis (drug therapy)
• Occupational Exposure
• Pancreatitis (complications, drug therapy)
• Quality Control