[The clinical research of serum soluble CD40L and high sensitivie C-reactive protein in patients with acute coronary syndrome].

Abstract

AIM:

To explore the clinical significance and mechanism of soluble CD40 Ligand (sCD40L) and high sensitive C-reactive protein (hs-CRP) in patients with acute coronary syndrome(ACS).

METHODS:

A total of 86 consecutive patients with ACS were included in the study, according to the selection criteria for diagnosis of acute coronary syndrome (ACS), 86 patients were divided into two groups: normal and the ACS, In all patients, sCD40L and CRP levels were evaluated within 12 h. the incidence of acute cardiovascular events were observed after two months follow-up.

RESULTS:

The ACS group was obviously higher than control group (P<0.01), AMI group slightly higher than the UA group but had no significant difference (P>0.05). sCD40L and hs-CRP group of cardiovascular events increased more than the normal group.

CONCLUSION:

Acute coronary syndrome patients with early peripheral serum levels of sCD40L and hs-CRP were significantly increased, suggesting that CD40/CD40L system participate the occurrence of ACS, and the inflammatory factors such as C-reactive protein in collaboration, plays an important role on atherosclerotic plaque instability.

• Authors: Hong-Jie Fu, Ming Yuan, Li-Fen Ren, Wen-Yi Guo
• Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi) Vol. 27 Issue 2 Pg. 180-1 (Feb 2011) ISSN: 1007-8738 [Print] China
• PMID: 21315051 (Publication Type: English Abstract, Journal Article)

Chemical References

• CD40 Ligand
• C-Reactive Protein

Topics

• Acute Coronary Syndrome (diagnosis, physiopathology)
• Adult
• Aged
• C-Reactive Protein (metabolism)
• CD40 Ligand (blood)
• Case-Control Studies
• Female
• Humans
• Male
• Middle Aged
• Prognosis