Abstract | UNLABELLED: CONCLUSION: The constitutive activation of ERBB3-dependent signaling via the NRG1/ERBB3 autocrine loop plays a crucial role in the regulation of cell motility and invasion, which contribute to intrahepatic metastasis and early recurrence of HCC. ERBB3 is a marker for the prediction of intrahepatic metastasis and early recurrence. ERBB3-dependent signaling is a candidate target for the treatment of microscopic vascular invasion and for the prevention of HCC recurrence.
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Authors | Sen-Yung Hsieh, Jung-Ru He, Chih-Yun Hsu, Wan-Ju Chen, Rabindranath Bera, Kuo-Yang Lin, Tsung-Chieh Shih, Ming-Chin Yu, Yu-Jr Lin, Chee-Jen Chang, Wen-Hui Weng, Shiu-Fen Huang |
Journal | Hepatology (Baltimore, Md.)
(Hepatology)
Vol. 53
Issue 2
Pg. 504-16
(Feb 2011)
ISSN: 1527-3350 [Electronic] United States |
PMID | 21246584
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 American Association for the Study of Liver Diseases. |
Chemical References |
- Neuregulin-1
- RNA, Small Interfering
- Receptor, ErbB-3
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Topics |
- Autocrine Communication
(physiology)
- Carcinoma, Hepatocellular
(metabolism, mortality, pathology)
- Cell Line, Tumor
- Cell Movement
(physiology)
- Cell Proliferation
- Female
- Gene Silencing
(drug effects)
- Humans
- Kaplan-Meier Estimate
- Liver Neoplasms
(metabolism, mortality, pathology)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
- Neuregulin-1
(metabolism)
- Phosphorylation
(physiology)
- Prognosis
- RNA, Small Interfering
(pharmacology)
- Receptor, ErbB-3
(metabolism)
- Retrospective Studies
- Signal Transduction
(physiology)
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