Abstract | OBJECTIVE: METHODS: RESULTS: Mice given senkyunolide I at 16 and 32 mg/kg had significantly elevated pain thresholds in the hot-plate test, and a dose of 32 mg/kg also reduced the number of abdominal writhing responses caused by acetic acid. Significant improvements were observed in the neurotransmitter levels of the drug-treated rats compared with the saline-administered controls. Compared to the rats with nitroglycerin-induced migraines, the levels of nitric oxide in the plasma and whole brain of rats given senkyunolide I were lower. CONCLUSIONS:
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Authors | Yi-Han Wang, Shuang Liang, De-Sheng Xu, Xiao Lin, Chun-Yong He, Yi Feng, Yan-Long Hong |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 63
Issue 2
Pg. 261-6
(Feb 2011)
ISSN: 2042-7158 [Electronic] England |
PMID | 21235591
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society. |
Chemical References |
- Acetates
- Analgesics
- Benzofurans
- Drugs, Chinese Herbal
- Neurotransmitter Agents
- Nitric Oxide
- Serotonin
- Hydroxyindoleacetic Acid
- 3-N-butyl-4,5-dihydrophthalide
- 5-Hydroxytryptophan
- Nitroglycerin
- chuangxiong extract
- Dopamine
- Norepinephrine
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Topics |
- 5-Hydroxytryptophan
(blood, metabolism)
- Acetates
- Analgesics
(pharmacology)
- Animals
- Benzofurans
(isolation & purification, pharmacology)
- Brain
(drug effects, metabolism)
- Dopamine
(blood, metabolism)
- Drugs, Chinese Herbal
(chemistry, isolation & purification, pharmacology)
- Hydroxyindoleacetic Acid
(blood, metabolism)
- Ligusticum
- Mice
- Migraine Disorders
(chemically induced, drug therapy, metabolism)
- Neurotransmitter Agents
(blood, metabolism)
- Nitric Oxide
(blood, metabolism)
- Nitroglycerin
(pharmacology)
- Norepinephrine
(blood, metabolism)
- Pain Threshold
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Serotonin
(blood, metabolism)
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