A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk.

Abstract

Multiple genetic and environmental factors underlie the etiology of type 2 diabetes. To evaluate the influence of the relationship between dietary fat intake and single nucleotide polymorphisms (SNPs) in genes involved in fat assimilation on disease susceptibility, a 2-step approach using an exploratory case-control study (n = 192/384) and an independent, confirmatory case-cohort study (n = 614/2248) taken from the same prospective study population (European Prospective Investigation into Cancer and Nutrition-Potsdam) was used. Sixty-three SNPs in 32 genes were initially analyzed. Total intake of fat and fatty acid intake were calculated from validated baseline FFQ. The SNP × nutrient interaction was tested in multivariate adjusted regression models. The initial screening step revealed evidence that, for 4 SNPs (CAV2 rs2270188, DBI rs2084202, PPARG rs1801282, and SREBF1 rs2297508), disease susceptibility might depend on the amount and quality of fat intake. The insulin receptor regulator CAV2 rs2270188 G > T SNP was found to interact with dietary fat in the confirmatory case-cohort study. Using pooled data, homozygous individuals of the rare T-allele showed a 100% greater risk of type 2 diabetes if daily fat intake was increased from 30 to 40 % energy. An increase in dietary SFA from 10 to 20 % energy predicted an ~200% greater risk of type 2 diabetes. We found preliminary evidence that CAV2 rs2270188 interacts with dietary fat to affect risk of type 2 diabetes.

• Authors: Eva Fisher, Stefan Schreiber, Hans-Georg Joost, Heiner Boeing, Frank Döring
• Journal: The Journal of nutrition (J Nutr) Vol. 141 Issue 2 Pg. 177-81 (Feb 2011) ISSN: 1541-6100 [Electronic] United States
• PMID: 21178094 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Caveolin 2
• Dietary Fats
• PPAR gamma
• SREBF1 protein, human
• Sterol Regulatory Element Binding Protein 1

Topics

• Adult
• Alleles
• Case-Control Studies
• Caveolin 2 (genetics)
• Diabetes Mellitus, Type 2 (genetics)
• Dietary Fats (adverse effects)
• Female
• Genetic Predisposition to Disease
• Humans
• Male
• Middle Aged
• Multivariate Analysis
• Nutrigenomics
• Nutritional Physiological Phenomena (genetics)
• PPAR gamma (genetics)
• Polymorphism, Single Nucleotide
• Prospective Studies
• Risk Factors
• Sterol Regulatory Element Binding Protein 1 (genetics)
• Surveys and Questionnaires