Pharmacological correction of testosterone deficiency during experimental myocardial ischemia.

Abstract

Experiments on rats with myocardial ischemia modeled by occlusion of the left coronary artery aggravated by alimentary dislipoproteinemia showed that therapy with taurepar (50 mg/kg), a taurine derivative, decreased blood corticosterone concentration and increased the level of endogenous testosterone, which attests to normalization of the compensatory-adaptive and gonadotropic functions of the organism.

• Authors: L K Khnychenko, I V Okunevich, Yu O Fedotova, N S Sapronov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 149 Issue 5 Pg. 601-3 (Oct 2010) ISSN: 1573-8221 [Electronic] United States
• PMID: 21165397 (Publication Type: Journal Article)

Chemical References

• Dietary Fats
• taurepar
• Taurine
• Testosterone
• Corticosterone

Topics

• Animals
• Corticosterone (blood)
• Dietary Fats (administration & dosage)
• Dyslipidemias (drug therapy)
• Male
• Myocardial Ischemia (complications, physiopathology)
• Rats
• Taurine (analogs & derivatives, therapeutic use)
• Testosterone (blood, deficiency)