Determining prognosis in childhood acute lymphoblastic leukemia by phytohemagglutinin (PHA) stimulated lymphocytes.

Abstract

The cellular immunity of 49 children between the ages of five months and 17 years with acute lymphoblastic leukemia (ALL) in remission was studied in vitro by stimulating the lymphocyte cultures with phytohemagglutinin (PHA). The mitogenic responses of the lymphocytes were followed for seven days in short term tissue culture and the maximum peak days were correlated to the disease-free period. The patients who had the maximum mitogenic response on day five or later had a significantly better prognosis than patients who peaked on day four or earlier.

• Authors: T Sumer, L F Sinks
• Journal: Annals of Saudi medicine (Ann Saudi Med) Vol. 6 Issue 1 Pg. 9-14 (Jan 1986) ISSN: 0256-4947 [Print] Saudi Arabia
• PMID: 21164233 (Publication Type: Journal Article)