Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.

Abstract	Obliterative bronchiolitis (OB) has been a major obstacle to long-term allograft survival after lung transplantation, and the underlying mechanism is not well understood. As IL-23/IL-17 pathway has been shown to play important roles in airway inflammation, in this study we have investigated the role of IL-23/IL-17 pathway in acute and chronic airway allograft rejection. We used a rat OB model in orthotopic tracheal transplantation, and investigated the effects of anti-IL-23 blockade antibody on acute and chronic airway allograft rejection. Anti-IL-23 antibody impaired the function of IL-23 in inducing IL-17 production. The rats that received allografts and treated with anti-IL-23 antibody showed significantly less symptom of airway obliteration and chronic transplant rejection compared with control rats which received physiological saline or IgG antibody. Taken together, our results suggest that anti-IL-23 antibody is effective in protecting allograft rejection and the development of chronic OB in allo-tracheal transplantation. These findings may have implications for new therapies to prevent OB and allograft rejection in human lung transplantation.
Authors	Hao Cao, Qin Lan, Qian Shi, Xiaohui Zhou, Gang Liu, Jian Liu, Guangliang Tang, Chenli Qiu, Chao Qiu, Jianqing Xu, Huimin Fan, Zhongmin Liu
Journal	International immunopharmacology (Int Immunopharmacol) Vol. 11 Issue 5 Pg. 569-75 (May 2011) ISSN: 1878-1705 [Electronic] Netherlands
PMID	21094688 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2010 Elsevier B.V. All rights reserved.
Chemical References	Antibodies, Blocking Interleukin-17 Interleukin-23
Topics	Airway Obstruction Animals Antibodies, Blocking (administration & dosage) Cells, Cultured Chronic Disease Disease Progression Graft Rejection (immunology, physiopathology, prevention & control) Interleukin-17 (genetics, immunology, metabolism) Interleukin-23 (genetics, immunology, metabolism) Organ Transplantation Rats Rats, Inbred Lew Signal Transduction (drug effects, immunology) Trachea (transplantation)

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