Abstract | BACKGROUND:
Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS. METHODS: RESULTS: The G/G genotype was significantly more common in MDS patients (47/187; 25.1%) than in controls (6/95; 6.3%) or in patients with other leukemias (101/813; 12.4%) (all P < 0.001). Individuals with the G/G genotype were more likely than those with other genotypes to have MDS (odd ratio = 4.98; 95% CI = 2.04-12.13). Clinical and follow up data were available for 112 MDS patients and 186 AML patients. There was no correlation between EPO promoter genotype and response to therapy or overall survival in MDS or AML. In the MDS group, the GG genotype was significantly associated with shorter complete remission duration, as compared with the TT genotype (P = 0.03). Time to neutrophils recovery after therapy was significantly longer in MDS patients with the G/G genotype (P = 0.02). CONCLUSIONS: These findings suggest a strong association between the rs1617640 G/G genotype and MDS. Further studies are warranted to investigate the utility of screening for this marker in individuals exposed to environmental toxins or chemotherapy.
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Authors | Wanlong Ma, Hagop Kantarjian, Ke Zhang, Xi Zhang, Xiuqiang Wang, Clifford Chen, Amber C Donahue, Zhong Zhang, Chen-Hsiung Yeh, Susan O'Brien, Guillermo Garcia-Manero, Neil Caporaso, Ola Landgren, Maher Albitar |
Journal | BMC medical genetics
(BMC Med Genet)
Vol. 11
Pg. 163
(Nov 16 2010)
ISSN: 1471-2350 [Electronic] England |
PMID | 21078205
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Erythropoietin
(genetics)
- Genetic Association Studies
- Genotype
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute
- Middle Aged
- Myelodysplastic Syndromes
(genetics, therapy)
- Polymorphism, Genetic
(genetics)
- Polymorphism, Single Nucleotide
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Promoter Regions, Genetic
(genetics)
- Treatment Outcome
- Young Adult
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