Abstract | AIMS: To assess self-reported lifetime prevalence of cardiovascular disease (CVD) among colorectal cancer survivors, and examine the cross-sectional and prospective associations of lifestyle factors with co-morbid CVD. METHODS:
Colorectal cancer survivors were recruited (n=1966). Data were collected at approximately 5, 12, 24 and 36 months post-diagnosis. Cross-sectional findings included six CVD categories (hypercholesterolaemia, hypertension, diabetes, heart failure, kidney disease and ischaemic heart disease (IHD)) at 5 months post-diagnosis. Longitudinal outcomes included the probability of developing (de novo) co-morbid CVD by 36 months post-diagnosis. Lifestyle factors included body mass index, physical activity, television (TV) viewing, alcohol consumption and smoking. RESULTS: Co-morbid CVD prevalence at 5 months post-diagnosis was 59%, and 16% of participants with no known CVD at the baseline reported de novo CVD by 36 months. Obesity at the baseline predicted de novo hypertension (odds ratio [OR]=2.20, 95% confidence intervals [CI]=1.09, 4.45) and de novo diabetes (OR=6.55, 95% CI=2.19, 19.53). Participants watching >4h of TV/ d at the baseline (compared with <2h/d) were more likely to develop ischaemic heart disease by 36 months (OR=5.51, 95% CI=1.86, 16.34). CONCLUSION:
Overweight colorectal cancer survivors were more likely to suffer from co-morbid CVD. Interventions focusing on weight management and other modifiable lifestyle factors may reduce functional decline and improve survival.
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Authors | Anna L Hawkes, Brigid M Lynch, Neville Owen, Joanne F Aitken |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 47
Issue 2
Pg. 267-76
(Jan 2011)
ISSN: 1879-0852 [Electronic] England |
PMID | 21074408
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Ltd. All rights reserved. |
Topics |
- Adult
- Aged
- Alcohol Drinking
(adverse effects)
- Cardiovascular Diseases
(complications, epidemiology)
- Colorectal Neoplasms
(complications, epidemiology)
- Cross-Sectional Studies
- Exercise
(physiology)
- Female
- Humans
- Leisure Activities
- Life Style
- Male
- Middle Aged
- Overweight
(complications)
- Prospective Studies
- Queensland
(epidemiology)
- Risk Factors
- Smoking
(adverse effects)
- Socioeconomic Factors
- Survivors
(statistics & numerical data)
- Young Adult
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