Abstract |
Antifungal testing results from the SENTRY Antimicrobial Surveillance Program (2008 to 2009) were analyzed for regional variations of invasive Candida species infections. Among 2,085 cases from the Asian-Pacific (APAC) (51 cases), Latin American ( LAM) (348 cases), European (EU) (750 cases), and North American (NAM) (936 cases) regions, Candida albicans predominated (48.4%), followed by C. glabrata (18.0%), C. parapsilosis (17.2%), C. tropicalis (10.5%), and C. krusei (1.9%). Resistance to echinocandins ( anidulafungin [2.4%] and micafungin [1.9%]) and azoles (3.5 to 5.6%) was most prevalent among C. glabrata isolates, as determined using recently established CLSI breakpoint criteria. C. glabrata isolates were more common in NAM (23.5%), and C. albicans isolates were more common in APAC (56.9%), with C. parapsilosis (25.6%) and C. tropicalis (17.0%) being more prominent in LAM. Emerging resistance patterns among C. glabrata cases in NAM require focused surveillance.
|
Authors | Michael A Pfaller, Gary J Moet, Shawn A Messer, Ronald N Jones, Mariana Castanheira |
Journal | Journal of clinical microbiology
(J Clin Microbiol)
Vol. 49
Issue 1
Pg. 396-9
(Jan 2011)
ISSN: 1098-660X [Electronic] United States |
PMID | 21068282
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antifungal Agents
- Azoles
- Echinocandins
|
Topics |
- Antifungal Agents
(pharmacology)
- Azoles
(pharmacology)
- Candida
(classification, drug effects, isolation & purification)
- Candidiasis
(microbiology)
- Echinocandins
(pharmacology)
- Fungemia
(microbiology)
- Geography
- Humans
- Microbial Sensitivity Tests
|