[Expression of PCNA, BCL-2, CD4+, CD8+ in the adenoid tissues from children with secretory otitis media].

Abstract

OBJECTIVE:

To investigate the relationship between immune status of adenoids and secretory otitis media (SOM).

METHOD:

The adenoid tissue samples of 72 cases with SOM and 30 cases with adenoid hypertrophy without SOM were studied by immunohistochemical method.

RESULT:

The PCNA, BCL-2, CD4+, CD8+ and CD4+ / CD8+ in SOM tissue samples were 30.85 +/- 1.73, 21.27 +/- 1.25, 41.90 +/- 9.07, 20.45 +/- 7.08 and 2.10 +/- 0.17, respectively, which were much more than that of tissue samples without SOM (25.25 +/- 1.75, 14.05 +/- 1.02, 16.30 +/- 8.21, 11.15 +/- 5.71, 1.39 +/- 0.15 respectively) (P < 0.01). The expression of CD4+ in T-lymphocyte was obviously higher than that of CD8+.

CONCLUSION:

In adenoid tissues of SOM patients, the activity of T-lymphocyte subsets are increased,the adenoids are enlarged and local immunity are enhanced. Therefore,adenoidectomy should be applied in SOM patients as early as possible.

• Authors: Shujun Zhang, Yuli Zhang, Zhuoli Yue, Guiru Yin, Yingchun Wang, Qinghong Li
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 24 Issue 16 Pg. 740-2 (Aug 2010) ISSN: 2096-7993 [Print] China
• PMID: 21033101 (Publication Type: English Abstract, Journal Article)

Chemical References

• Proliferating Cell Nuclear Antigen
• Proto-Oncogene Proteins c-bcl-2

Topics

• Adenoids (immunology, metabolism)
• CD4-Positive T-Lymphocytes (immunology)
• CD8-Positive T-Lymphocytes (immunology)
• Child
• Child, Preschool
• Female
• Humans
• Male
• Otitis Media with Effusion (immunology, metabolism)
• Proliferating Cell Nuclear Antigen (metabolism)
• Proto-Oncogene Proteins c-bcl-2 (metabolism)