Degenerative changes, DNA synthesis and mitotic activity in rat liver following single and repeated exposure to fenarimol.

Abstract	Degenerative changes were observed in liver of rats treated with single and repeated doses of fenarimol (250 mg/kg body weight x day). Regenerative changes i.e. increase in: DNA synthesis, hepatic DNA, mitotic activity and number of binuclear hepatocytes, were also noted.
Authors	D Palut, J Kopeć-Szlezak
Journal	Roczniki Panstwowego Zakladu Higieny (Rocz Panstw Zakl Hig) Vol. 41 Issue 5-6 Pg. 253-61 ( 1990) ISSN: 0035-7715 [Print] Poland
PMID	2101177 (Publication Type: Comparative Study, Journal Article)
Chemical References	Fungicides, Industrial Pyrimidines DNA fenarimol
Topics	Animals Cell Count (drug effects) DNA (biosynthesis, drug effects) Disease Models, Animal Dose-Response Relationship, Drug Fatty Liver (chemically induced, metabolism, pathology) Fungicides, Industrial (administration & dosage, toxicity) Liver (drug effects, metabolism, pathology) Male Mitosis (drug effects) Pyrimidines (administration & dosage, toxicity) Rats Rats, Inbred Strains

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