Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia.

Abstract

CONTEXT:

A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.

OBJECTIVE:

We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.

MATERIALS AND METHODS:

Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.

RESULTS AND CONCLUSIONS:

We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

• Authors: Maarten J ten Berg, Albert Huisman, Patricia M L A van den Bemt, Hanneke den Breeijen, Toine C G Egberts, Wouter W van Solinge
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 16 Issue 1 Pg. 51-7 (Feb 2011) ISSN: 1366-5804 [Electronic] England
• PMID: 20977409 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Biomarkers, Pharmacological

Topics

• Adult
• Aged
• Antineoplastic Agents (adverse effects, pharmacology, therapeutic use)
• Biomarkers, Pharmacological (blood)
• Blood Platelets (pathology)
• Cell Size (drug effects)
• Drug-Related Side Effects and Adverse Reactions
• Female
• Humans
• Male
• Middle Aged
• Neoplasms (drug therapy)
• Platelet Count
• Retrospective Studies
• Thrombocytopenia (chemically induced, pathology)