Abstract | BACKGROUND: METHODS: Primary breast cancer surgery patients were randomized to propofol/paravertebral (n = 15) or sevoflurane/ opioid (n = 17) and preoperative and postoperative serum concentrations of 11 cytokines ( interleukin 1β [IL-1β], IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon γ, and tumor necrosis factor α) and 3 MMPs (MMP-1, MMP-3, and MMP-9) were measured. RESULTS: Treatment groups were well balanced for age, weight, surgical procedure, and cancer pathologic diagnosis. Pain scores were lower at 1 and 2 hrs with paravertebral analgesia compared with morphine but similar at 24 hrs. Patients in the propofol/paravertebral group showed a greater percentage decrease in postoperative compared with preoperative IL-1β (median [quartiles], -26% [-15% to -52%] versus -4% [-14% to 2%], P = 0.003), a significant attenuation in elevated MMP-3 (2% [-39% to 12%] versus 29% [23%-59%], P = 0.011) and MMP-9 (26% [13%-54%] versus 74% [50%-108%], P = 0.02), and a significant increase in IL-10 (10% [5%-33%] versus -15% [20% to -2%], P = 0.001) compared with sevoflurane/ opioid group. No significantly different changes in IL-2, IL-4, IL-5, IL-6, IL-8, IL-12p70, IL-13, interferon γ, tumor necrosis factor α, or MMP-1 were observed between the 2 groups. CONCLUSIONS:
|
Authors | Catherine A Deegan, David Murray, Peter Doran, Denis C Moriarty, Daniel I Sessler, Ed Mascha, Brian P Kavanagh, Donal J Buggy |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2010 Nov-Dec
Vol. 35
Issue 6
Pg. 490-5
ISSN: 1532-8651 [Electronic] England |
PMID | 20975461
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Analgesics, Opioid
- Anesthetics, Inhalation
- Anesthetics, Intravenous
- Anesthetics, Local
- Cytokines
- Interleukins
- Methyl Ethers
- Tumor Necrosis Factor-alpha
- Sevoflurane
- Morphine
- Interferon-gamma
- Levobupivacaine
- Matrix Metalloproteinases
- MMP3 protein, human
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 9
- MMP1 protein, human
- Matrix Metalloproteinase 1
- Bupivacaine
- Propofol
|
Topics |
- Aged
- Analgesics, Opioid
(administration & dosage)
- Anesthesia, Conduction
- Anesthetics, Inhalation
(administration & dosage)
- Anesthetics, Intravenous
(administration & dosage)
- Anesthetics, Local
(administration & dosage)
- Breast Neoplasms
(enzymology, immunology, pathology, surgery)
- Bupivacaine
(administration & dosage, analogs & derivatives)
- Cytokines
(blood)
- Female
- Humans
- Immunity, Cellular
(drug effects)
- Interferon-gamma
(blood)
- Interleukins
(blood)
- Ireland
- Levobupivacaine
- Mastectomy
- Matrix Metalloproteinase 1
(blood)
- Matrix Metalloproteinase 3
(blood)
- Matrix Metalloproteinase 9
(blood)
- Matrix Metalloproteinases
(blood)
- Methyl Ethers
(administration & dosage)
- Middle Aged
- Morphine
(administration & dosage)
- Nerve Block
- Pain, Postoperative
(etiology, prevention & control)
- Pilot Projects
- Propofol
(administration & dosage)
- Sevoflurane
- Time Factors
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(blood)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|