Association of renin BglI polymphism with essential hypertension: a meta-analysis involving 1811 cases and 1626 controls.

Abstract

In an effort to clarify association of an intronic polymorphism BglI in a renin gene with essential hypertension, we performed a meta-analysis of the case-control association studies. Publications in the English language and human subjects were searched in PubMed and EMBASE as of July 10, 2009. A fixed-effects model was applied to pool data in the absence of between-studies heterogeneity, and a random-effects model otherwise. Data and study quality were assessed in duplicate. Publication bias was evaluated using the fail-safe number. From three studies with four populations including 1811 patients with essential hypertension and 1626 controls, we found a significant association of renin BglI B with an increased risk for essential hypertension (OR = 1.25; 95% CI, 1.11 to 1.41; P = 0.0002). In addition, significance persisted after assuming the dominant (OR = 1.30; 95% CI, 1.13 to 1.51; P = 0.0004) mode of inheritance, while no significance was observed for the recessive mode (OR = 1.46; 95% CI, 0.82 to 2.60; P = 0.20). The fail-safe number at the level of 0.05 supported these significant associations. In sum, our meta-analysis expands previous findings by showing that the presence of renin BglI B allele is associated with an increased risk in developing essential hypertension, and this effect might act in a dominant mode of inheritance. Further studies are warranted to fully address questions about the etiologic mechanisms of this positive association.

• Authors: Wenquan Niu, Yue Qi, Shujie Guo, Pingjin Gao, Dingliang Zhu
• Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) (Clin Exp Hypertens) Vol. 32 Issue 7 Pg. 431-8 ( 2010) ISSN: 1525-6006 [Electronic] England
• PMID: 20925572 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Renin

Topics

• Adult
• Alleles
• Blood Pressure (genetics)
• Female
• Genetic Association Studies
• Humans
• Hypertension (etiology, genetics)
• Inheritance Patterns
• Male
• Models, Statistical
• Odds Ratio
• Polymorphism, Single Nucleotide
• Renin (genetics)
• Renin-Angiotensin System (genetics)
• Risk Assessment
• Vasoconstriction (genetics)