Abstract | OBJECTIVE: PATIENTS AND METHODS: • All patients with CP/CPPS underwent a complete history and physical examination, and were scored according to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). • Expressed prostatic secretion samples from 20 patients with CP/CPPS and from four asymptomatic control patients were collected and frozen, and NGF levels in EPS were measured by enzyme-linked immunosorbent assay. • Patients were asked to complete NIH-CPSI questionnaires at baseline and 8 weeks after treatment and patients with at least a 25% decrease in total NIH-CPSI score from the baseline values were classified as responders to treatment. RESULTS: • The mean (± sd) NGF levels in EPS of patients with CP/CPPS and asymptomatic control patients were 7409 (± 3788) pg/mL and 4174 (± 1349) pg/mL, respectively. The NGF level in patients with CP/CPPS correlated directly with pain severity (P= 0.014, r= 0.541). • There were no significant differences between NGF levels in EPS before and after treatment. However, successful treatment significantly decreased NGF levels in responders (P= 0.001). CONCLUSION: • Nerve growth factor might contribute to the pathophysiology of CP/CPPS as changes in NGF level in EPS occurred in proportion to pain severity. Therefore, these results suggest that NGF could be used as a new biomarker to evaluate the symptoms of CP/CPPS and the effects of treatment.
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Authors | Toyohiko Watanabe, Miayabi Inoue, Katsumi Sasaki, Motoo Araki, Shinya Uehara, Koichi Monden, Takashi Saika, Yasutomo Nasu, Hiromi Kumon, Michael B Chancellor |
Journal | BJU international
(BJU Int)
Vol. 108
Issue 2
Pg. 248-51
(Jul 2011)
ISSN: 1464-410X [Electronic] England |
PMID | 20883485
(Publication Type: Journal Article)
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Copyright | © 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL. |
Chemical References |
- Adrenergic alpha-Antagonists
- Biomarkers
- Naphthalenes
- Piperazines
- Quinolones
- Nerve Growth Factor
- naftopidil
|
Topics |
- Adrenergic alpha-Antagonists
(therapeutic use)
- Adult
- Aged
- Biomarkers
(metabolism)
- Bodily Secretions
- Enzyme-Linked Immunosorbent Assay
- Epidemiologic Methods
- Humans
- Magnetic Field Therapy
- Male
- Middle Aged
- Naphthalenes
(therapeutic use)
- Nerve Growth Factor
(metabolism)
- Pain Measurement
- Piperazines
(therapeutic use)
- Prostate
(metabolism)
- Prostatitis
(diagnosis, physiopathology, therapy)
- Quinolones
(therapeutic use)
- Treatment Outcome
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