Usefulness of magnifying endoscopy for iodine-unstained lesions in a high-risk esophageal cancer population.

Abstract

AIM:

To investigate the usefulness of magnified observations of iodine-unstained esophageal lesions in the histological diagnosis of esophageal mucosa abnormalities, in high-risk esophageal cancer groups.

METHODS:

The subjects included 38 patients who had at least one of the four criteria known to be high-risk factors for esophageal cancer. Following endoscopic observation, magnified observations were performed on iodine-unstained lesions of the esophagus. The total number of lesions was 43. These lesions were classified as type A (clear papilla), type B (fused papilla), and type C (non-visible papilla) according to the findings. Tissue biopsy was then carried out. Finally the histological findings were graded in terms of histological factors, and their relationships were compared.

RESULTS:

Of the 43 lesions, 11 were type A, 17 were type B, and 15 were type C under magnifying endoscopy. Histological findings such as inflammatory cell infiltration and basal cell hyperplasia were significantly increased in type B and type C lesions compared with type A lesions (P < 0.05). Low-grade esophageal dysplasia was apparent in 1 (9%) of 11 type A lesions, in 3 (18%) of 17 type B lesions, and in 6 (40%) of 15 type C lesions, with the highest rate in type C.

CONCLUSION:

Magnified observations of the esophagus, classified by papillary aspects using magnifying endoscopy of iodine-unstained lesions in high-risk esophageal cancer groups, are considered useful in estimating dysplasia and inflammation of esophageal mucosa.

• Authors: Ik Seong Choi, Jae Young Jang, Won Young Cho, Tae Hee Lee, Hyun Gun Kim, Bo Young Lee, Soung Won Jeong, Joo Young Cho, Joon Seong Lee, So Young Jin
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 16 Issue 37 Pg. 4709-15 (Oct 07 2010) ISSN: 2219-2840 [Electronic] United States
• PMID: 20872973 (Publication Type: Journal Article)

Chemical References

• Iodine

Topics

• Adult
• Aged
• Aged, 80 and over
• Esophageal Neoplasms (diagnosis, pathology)
• Esophagoscopy (methods)
• Female
• Humans
• Iodine
• Male
• Middle Aged
• Precancerous Conditions (diagnosis, pathology)
• Risk Factors