Determinants of serum-induced SIRT1 expression in older men: the CHAMP study.

Abstract

Circulating factors that have an effect on SIRT1 expression are influenced by caloric restriction. To determine the association between frailty and such circulating factors, we measured serum-induced SIRT1 expression from a nested cohort of frail (n = 77) and robust (n = 82) participants from Concord Health and Ageing in Men Project, a population-based study of community-dwelling men older than 70 years. Serum-induced SIRT1 expression was not different between frail and robust men (103.1 ± 17.0 versus 100.4 ± 19.3 μg/L). However, subsequent analyses showed that men with the lowest values (first quartile) were less likely to be frail (odds ratio = 0.5, 95% confidence interval = 0.2-1.0, p = .04) and had higher total body lean mass (p = .001) than the other participants. Serum-induced SIRT1 expression did not correlate with age, diseases, medications, albumin, fasting glucose, or lipids. Overall, there was no association between frailty and serum-induced SIRT1 expression; however, post hoc analysis suggested that there might be a paradoxical association between low serum-induced SIRT1 expression and robustness.

• Authors: David G Le Couteur, Vicky L Benson, Aisling C McMahon, Fiona Blyth, David J Handelsman, Markus J Seibel, Marina Kennerson, Vasi Naganathan, Robert G Cumming, Rafael de Cabo
• Journal: The journals of gerontology. Series A, Biological sciences and medical sciences (J Gerontol A Biol Sci Med Sci) Vol. 66 Issue 1 Pg. 3-8 (Jan 2011) ISSN: 1758-535X [Electronic] United States
• PMID: 20819794 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• SIRT1 protein, human
• Sirtuin 1

Topics

• Aged
• Aged, 80 and over
• Case-Control Studies
• Cohort Studies
• Frail Elderly
• Humans
• Male
• Serum (physiology)
• Sirtuin 1 (biosynthesis)