Abstract | AIMS: METHODS AND RESULTS: Patients with ACS (n = 241) or high-risk CAD (n = 263) received E5555 (50, 100, or 200 mg) or placebo once daily for 12 (ACS patients) or 24 weeks (CAD patients). The incidence of TIMI major, minor, and minimal bleeds requiring medical attention was similar in the placebo and combined E5555 ( atopaxar) groups (ACS: 6.6% placebo vs. 5.0% E5555; CAD: 1.5% placebo vs. 1.5% E5555). There were no TIMI major bleeds and three CURE major bleeds (two with placebo; one with 100 mg E5555). There was a numerical increase in 'any' TIMI bleeding with the E5555 200 mg dose (ACS: 16.4% placebo vs. 23.0% E5555, P = 0.398; CAD: 4.5% placebo vs. 13.2% E5555, P = 0.081). The rate of major cardiovascular adverse events in the combined E5555 group was not different from placebo (ACS: 6.6% placebo vs. 5.0% E5555, P = 0.73; CAD: 4.5% placebo vs. 1.0% E5555, P = 0.066). There was a statistically significant dose-dependent increase in liver function abnormalities and QTcF with E5555. At trough dosing levels in both populations, mean inhibition of platelet aggregation was > 90% with 100 and 200 mg E5555, and 20-60% with 50 mg E5555. CONCLUSION: E5555 (50, 100, and 200 mg) did not increase clinically significant bleeding, although there was a higher rate of any TIMI bleeding with the highest two doses. All doses tested achieved a significant level of platelet inhibition. There was a significant dose-dependent increase in liver function abnormalities and QTcF. Although further study is needed, PAR-1 antagonism may have the potential to be a novel pathway for platelet inhibition to add on to the current standard of care therapy.
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Authors | Shinya Goto, Hisao Ogawa, Masaru Takeuchi, Marcus D Flather, Deepak L Bhatt, J-LANCELOT (Japanese-Lesson from Antagonizing the Cellular Effect of Thrombin) Investigators |
Journal | European heart journal
(Eur Heart J)
Vol. 31
Issue 21
Pg. 2601-13
(Nov 2010)
ISSN: 1522-9645 [Electronic] England |
PMID | 20805115
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- E 5555
- Imines
- Platelet Aggregation Inhibitors
- Pyridines
- Receptor, PAR-1
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Topics |
- Acute Coronary Syndrome
(drug therapy)
- Administration, Oral
- Chemical and Drug Induced Liver Injury
(etiology)
- Coronary Artery Disease
(drug therapy)
- Double-Blind Method
- Female
- Hemorrhage
(chemically induced)
- Humans
- Imines
(administration & dosage)
- Long QT Syndrome
(chemically induced)
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
(administration & dosage)
- Pyridines
(administration & dosage)
- Receptor, PAR-1
(antagonists & inhibitors)
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