Abstract | OBJECTIVE: DESIGN: We determined serum neurosteroid levels by gas chromatography/mass spectrometry ( allopregnanolone, pregnenolone) or radioimmunoassay ( dehydroepiandrosterone [ DHEA], progesterone, DHEA sulfate [DHEAS]) in 90 male veterans who served in the U.S. military after September 11, 2001. Self-reported pain symptoms were assessed in four areas ( low back pain, chest pain, muscle soreness, headache). Stepwise linear regression analyses were conducted to investigate the relationship between pain assessments and neurosteroids, with the inclusion of smoking, alcohol use, age, and history of traumatic brain injury as covariates. SETTING: Durham VA Medical Center. RESULTS: CONCLUSIONS:
Neurosteroids may be relevant to the pathophysiology of self-reported pain symptoms in this veteran cohort, and could represent future pharmacological targets for pain disorders.
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Authors | Jason D Kilts, Larry A Tupler, Francis J Keefe, Victoria M Payne, Robert M Hamer, Jennifer C Naylor, Rohana P Calnaido, Rajendra A Morey, Jennifer L Strauss, Gillian Parke, Mark W Massing, Nagy A Youssef, Lawrence J Shampine, tVeterans Affairs Mid-Atlantic Mental Illness, Research, Education and Clinical Center Workgroup, Christine E Marx |
Journal | Pain medicine (Malden, Mass.)
(Pain Med)
Vol. 11
Issue 10
Pg. 1469-76
(Oct 2010)
ISSN: 1526-4637 [Electronic] England |
PMID | 20735755
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Wiley Periodicals, Inc. |
Chemical References |
- Neurotransmitter Agents
- Dehydroepiandrosterone
- Pregnanolone
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Topics |
- Adult
- Afghanistan
- Brain Injuries
(complications)
- Dehydroepiandrosterone
(pharmacology)
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Linear Models
- Male
- Military Personnel
- Neurotransmitter Agents
(metabolism)
- Pain
(metabolism)
- Pain Measurement
- Pregnanolone
(blood)
- Smoking
(metabolism)
- United States
- Veterans
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