Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes.

Abstract

OBJECTIVE:

Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.

RESEARCH DESIGN AND METHODS:

Subjects ingested a mixed meal (50% carbohydrates, 15% proteins, and 35% lipids) containing 0 g (control) or 10 g C10 in addition to the meal or 23 g C10 as a substitute of fats.

RESULTS:

In type 2 diabetic subjects, the incremental glucose area under the curve (AUC) decreased by 42% (P<0.05) and 70% (P<0.05) in the 10 g C10 and 23 g C10 groups, respectively. At the largest amounts used, C10 reduced the glucose AUC in healthy volunteers also. When fats were substituted with 23 g C10, AUC of Ra was significantly reduced on the order of 18% (P<0.05) in both healthy and diabetic subjects. The insulin-dependent glucose uptake by L6 cells was increased in the presence of C10 (38.7±10.3 vs. 11.4±5.4%; P=0.026). This increase was associated with a 1.7-fold raise of GLUT4.

CONCLUSIONS:

Sebacic acid significantly reduced hyperglycemia after a meal in type 2 diabetic subjects. This beneficial effect was associated with a reduction in glucose Ra, probably due to lowered hepatic glucose output and increased peripheral glucose disposal.

• Authors: Amerigo Iaconelli, Amalia Gastaldelli, Chiara Chiellini, Donatella Gniuli, Angela Favuzzi, Christophe Binnert, Katherine Macé, Geltrude Mingrone
• Journal: Diabetes care (Diabetes Care) Vol. 33 Issue 11 Pg. 2327-32 (Nov 2010) ISSN: 1935-5548 [Electronic] United States
• PMID: 20724647 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Blood Glucose
• C-Peptide
• Decanoic Acids
• Dicarboxylic Acids
• Insulin
• sebacic acid

Topics

• Absorptiometry, Photon
• Animals
• Biological Transport (drug effects)
• Blood Glucose (metabolism)
• Blotting, Western
• Body Composition (drug effects)
• C-Peptide (blood)
• Cell Line
• Decanoic Acids (administration & dosage, pharmacology, therapeutic use)
• Diabetes Mellitus, Type 2 (diet therapy, metabolism)
• Dicarboxylic Acids (administration & dosage, pharmacology, therapeutic use)
• Female
• Gas Chromatography-Mass Spectrometry
• Humans
• Immunoprecipitation
• Insulin (blood)
• Male
• Middle Aged
• Postprandial Period (drug effects)
• Rats