Patterns of recurrence and role of adjuvant chemotherapy in stage II-IV serous ovarian borderline tumors.

Abstract

OBJECTIVE:

The objective of this study was to evaluate patterns of recurrence and prognostic factors as well as the role of adjuvant chemotherapy in stage II-IV ovarian SBT.

METHODS:

We performed a retrospective review of all patients with advanced-stage SBT treated at our institution from 1979 to 2008. Advanced stage was defined as FIGO stage II-IV. Progression-free survival (PFS) was defined as the time of diagnosis to time of recurrence/death or last follow-up. Kaplan-Meier method was used to report the PFS rate.

RESULTS:

A total of 80 stage II-IV patients were identified, of which 15 (19%) were stage II, 63 (79%) were stage III, and 2 (2.5%) were stage IV. The site of metastasis was pelvis in 15 patients (19%), omentum in 29 patients (36%), isolated lymph nodes in 2 patients (2.5%), lung in 1 patient (1%), axilla in 1 patient (1%), and multiple sites in 32 patients (40%). With a median follow-up of 4.8 years, 17 patients (21%) developed recurrent disease. Only patients with metastasis to the omentum or multiple sites developed recurrent disease. Of the 65 stage III/IV patients, 17 patients (26%) received adjuvant chemotherapy following diagnosis. The 3-year progression-free survival (PFS) was 89.9% (95% CI, 77.3-95.7) for patients who did not receive adjuvant chemotherapy compared with 70.6% (95% CI, 43.1-86.6) for patients who received adjuvant chemotherapy.

CONCLUSIONS:

While advanced-stage ovarian SBT generally has a good prognosis, nearly 21% of patients develop recurrent disease with intermediate follow-up. It is unclear from these data if adjuvant chemotherapy influenced PFS.

• Authors: Karin K Shih, Qin C Zhou, Carol Aghajanian, Jae Huh, Robert A Soslow, Jessica C Morgan, Alexia Iasonos, Dennis S Chi, Richard R Barakat, Nadeem R Abu-Rustum
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 119 Issue 2 Pg. 270-3 (Nov 2010) ISSN: 1095-6859 [Electronic] United States
• PMID: 20719369 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Chemotherapy, Adjuvant
• Cystadenocarcinoma, Serous (drug therapy, pathology, surgery)
• Disease-Free Survival
• Female
• Humans
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (pathology)
• Neoplasm Staging
• Ovarian Neoplasms (drug therapy, pathology, surgery)
• Retrospective Studies
• Young Adult