Abstract | BACKGROUND: METHODS: We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort of men and women 55 to 74 years of age at baseline to test whether prediagnostic circulating IGF-I, IGF-II, IGFBP-3, and IGF-I/ IGFBP-3 molar ratio concentrations were associated with exocrine pancreatic cancer risk. Between 1994 and 2006, 187 incident cases of pancreatic adenocarcinoma occurred (follow-up of up to 11.7 years). Two controls (n = 374), who were alive at the time the case was diagnosed, were selected for each case and matched by age, race, sex, and date of blood draw. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) with the use of conditional logistic regression, adjusting for smoking. RESULTS:
IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly associated with pancreatic cancer (highest compared with lowest quartile: OR, 1.58; 95% CI, 0.91-2.76; and P-trend = 0.25; OR, 0.86; 95% CI, 0.49-1.50; and P-trend = 0.31; and OR, 0.88; 95% CI, 0.51-1.51; and P-trend = 0.47, respectively). However, a significant positive trend was observed with high IGF-I/ IGFBP-3 molar ratio levels (highest compared with lowest quartile: OR, 1.54; 95% CI, 0.89-2.66; P-trend = 0.04). CONCLUSION: IMPACT: Our results highlight the importance of this biomarker for further investigation in large prospective cohort studies and pooled analysis with other prospective cohorts.
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Authors | Jason B Douglas, Debra T Silverman, Michael N Pollak, Yuzhen Tao, Amr S Soliman, Rachael Z Stolzenberg-Solomon |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 19
Issue 9
Pg. 2298-306
(Sep 2010)
ISSN: 1538-7755 [Electronic] United States |
PMID | 20699371
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Copyright | (c)2010 AACR. |
Chemical References |
- Biomarkers, Tumor
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
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Topics |
- Adenocarcinoma
(blood)
- Aged
- Biomarkers, Tumor
(blood)
- Case-Control Studies
- Cohort Studies
- Early Detection of Cancer
(methods)
- Female
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor I
(metabolism)
- Insulin-Like Growth Factor II
(metabolism)
- Male
- Middle Aged
- Pancreatic Neoplasms
(blood)
- Risk Factors
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