Abstract | INTRODUCTION: METHODS: Twenty-five pigs (40-50 kg) were anesthetized and a normothermic temperature of 38 degrees C was established utilising an endovascular cooling catheter in a closed-chest model. A Swan-Ganz catheter was placed in the pulmonary artery. Hemodynamic parameters were continuously monitored and blood gases were sampled every 30 min. Ischemia was induced by inflation of a PCI balloon in proximal LAD for 40 min. Sixteen pigs that have fulfilled predefined shock criteria were randomized to hypothermia (n=8), or normothermia (n=8). Hypothermia (33 degrees C) was induced after onset of reperfusion by using an endovascular temperature modulating catheter and was maintained until termination of the experiment. RESULTS: The pigs in the hypothermia group were cooled to <34 degrees C in approximately 45 min. 5/8 pigs in the normothermia group died while all pigs in the hypothermia group survived (p<0.01). Stroke volume and blood pressure were significantly higher in the hypothermia group (p<0.05), whereas heart rate was significantly lower in the hypothermia group (p=0.01). Cardiac output did not differ among the groups (p=0.13). Blood gas analysis revealed higher mixed venous oxygen saturation, pH, and base excess in the hypothermia group indicating less development of metabolic acidosis (p<0.05). CONCLUSIONS:
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Authors | Matthias Götberg, Jesper van der Pals, Göran K Olivecrona, Michael Götberg, Sasha Koul, David Erlinge |
Journal | Resuscitation
(Resuscitation)
Vol. 81
Issue 9
Pg. 1190-6
(Sep 2010)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 20627520
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Acidosis
(etiology, physiopathology)
- Animals
- Arrhythmias, Cardiac
(etiology)
- Blood Circulation
- Body Temperature
- Female
- Gases
(blood)
- Hemodynamics
- Hypothermia, Induced
- Kaplan-Meier Estimate
- Male
- Myocardial Infarction
(complications)
- Myocardial Ischemia
(complications, therapy)
- Myocardial Reperfusion
- Severity of Illness Index
- Shock, Cardiogenic
(etiology, mortality, physiopathology, therapy)
- Time Factors
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