Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.

Abstract

CAPSULE:

HLA-B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations.

OBJECTIVE:

KD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno-inflammatory process, cytokines activation, and genetic factors. We aimed to investigate if genetic variants of human lymphocyte antigen (HLA)-BAT2, 3, and 5 (BAT2, 3, and 5) could be used as markers of susceptibility in KD and CAA.

METHODS:

Individuals were divided into three groups: (1) normal controls; (2) KD with CAA; and (3) KD without CAA. Polymorphisms for BAT2 (-8671, 16483), BAT3 (8854, 2-24), and BAT5 (22655, 9569) were genotyped by PCR system with TaqMan allelic discrimination assay. Genotype/allelic frequencies and haplotypes (BAT2(-8671)-BAT2(16483)-BAT3(8854)-BAT3(2-24)-BAT5(22655)-BAT5(9569)) in each group were compared.

RESULTS:

Genotype distribution and allele frequency of BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms in each group were significantly different. BAT2 -8671*G, BAT3 8854*C, BAT5 22655*C, and 9569*A-related genotypes and alleles are correlated with the developments of KD and CAA. BAT haplotypes of ATTGTG and ATCATG are associated with higher susceptibilities of KD with CAA susceptibility.

CONCLUSION:

BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms as well as BAT haplotypes (ATTGTG and ATCATG) might be associated with higher KD susceptibility and CAA formation. HLA-B region polymorphisms might contribute to the pathogenesis of KD and CAA.

• Authors: Yao-Yuan Hsieh, Ying-Ju Lin, Chi-Chen Chang, Da-Yuan Chen, Chin-Mu Hsu, Yu-Kuo Wang, Kung-Hao Hsu, Fuu-Jen Tsai
• Journal: Journal of clinical laboratory analysis (J Clin Lab Anal) Vol. 24 Issue 4 Pg. 262-8 ( 2010) ISSN: 1098-2825 [Electronic] United States
• PMID: 20626023 (Publication Type: Journal Article)

Chemical References

• BAG6 protein, human
• Genetic Markers
• HLA-B Antigens
• Molecular Chaperones
• Proteins
• PRRC2A protein, human

Topics

• Chi-Square Distribution
• Child
• Child, Preschool
• Chromosomes, Human, Pair 6
• Coronary Aneurysm (genetics)
• Female
• Genetic Markers (genetics)
• Genetic Predisposition to Disease
• HLA-B Antigens (genetics)
• Haplotypes
• Humans
• Male
• Molecular Chaperones (genetics)
• Mucocutaneous Lymph Node Syndrome (genetics)
• Polymorphism, Single Nucleotide
• Proteins (genetics)