Abstract | INTRODUCTION: METHODS: After a 3-week placebo wash-out, 155 patients with an Office trough sitting systolic blood pressure (Office sitSBP) >or=160 mmHg and <180 mmHg were randomized to eprosartan 600 mg (n=78) or losartan 50 mg (n=77) once daily for 6 weeks. In patients not optimally responding to monotherapy (Office sitSBP>or=130 mmHg) 12.5 mg HCTZ was added as fixed combination once daily for 6 weeks. A 24-hour ambulatory blood pressure monitoring (ABPM) was performed at the end of wash-out and at the end of the fixed-combination period. RESULTS: No statistically significant difference was found between eprosartan/ HCTZ and losartan/ HCTZ on the primary endpoint (24-hour ABPM SBP) with an adjusted mean difference between treatments of 3.1 mmHg (95% CI: -0.32-6.59). However, the mean 24-hour ABPM SBP significantly decreased by 16.7 mmHg with eprosartan/ HCTZ and 20.3 mmHg with losartan/ HCTZ (P<0.001 vs. baseline). The mean Office sitSBP significantly decreased by 28.7 mmHg and 29.6 mmHg respectively, with eprosartan/ HCTZ and losartan/ HCTZ (P<0.001 vs.baseline and vs. monotherapy). CONCLUSION:
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Authors | Ettore Ambrosioni, Michele Bombelli, Giovanni Cerasola, Francesco Cipollone, Claudio Ferri, Irene Grazioli, Cristiana Leprotti, Giuseppe Mancia, Gabriella Melzi, Amedeo Mugellini, Giuseppe Mulè, Giuseppe Palasciano, Antonio Salvetti, Bruno Trimarco |
Journal | Advances in therapy
(Adv Ther)
Vol. 27
Issue 6
Pg. 365-80
(Jun 2010)
ISSN: 1865-8652 [Electronic] United States |
PMID | 20556561
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acrylates
- Angiotensin II Type 1 Receptor Blockers
- Antihypertensive Agents
- Diuretics
- Imidazoles
- Thiophenes
- Hydrochlorothiazide
- eprosartan
- Losartan
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Topics |
- Acrylates
(therapeutic use)
- Aged
- Analysis of Variance
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Blood Pressure Monitoring, Ambulatory
(instrumentation, methods)
- Diuretics
(therapeutic use)
- Double-Blind Method
- Drug Monitoring
(methods)
- Drug Therapy, Combination
- Female
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Hypertension
(diagnosis, drug therapy)
- Imidazoles
(therapeutic use)
- Losartan
(therapeutic use)
- Male
- Office Visits
- Severity of Illness Index
- Statistics, Nonparametric
- Systole
- Thiophenes
(therapeutic use)
- Treatment Outcome
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