[Association of single nucleotide polymorphisms of kallikrein 1 gene with cerebral hemorrhage in Changsha Han Chinese].

Abstract

OBJECTIVE:

To explore the association between single nucleotide polymorphisms (SNPs) of KLK1 gene and cerebral hemorrhage in Changsha Han Chinese.

METHODS:

Two hundred and seventy-three cerebral hemorrhage (CH) patients and 140 healthy controls were collected. The SNPs of rs5516 and rs5517 loci of KLK1 gene were analyzed by SNaPshot methods and direct sequencing.

RESULTS:

(1)Genotype and allele frequencies in rs5516 locus had no difference between the CH patients and controls (P> 0.05). However, the A allele frequency of the rs5517 locus in CH patients was higher than that in the control group (0.419, 0.321 respectively, P< 0.05). (2)In the control group,the levels of diastolic blood pressure (DBP) of the GA and AA genotype carriers of the rs5517 locus were significantly higher than those of the GG genotype (P< 0.05), while the levels of blood pressure were not significantly different among different genotypes of the rs5516 polymorphism in both CH patients and the control group(P> 0.05).

CONCLUSION:

Author's preliminary results suggested that the rs5517 polymorphism was associated with cerebral hemorrhage, while the rs5516 polymorphism was not in Changsha Han Chinese.

• Authors: Yi Zeng, Le Zhang, Zhong-yang Hu, Qi-dong Yang, Bao-qiong Liu, Ming-ming Ma, Yun-hai Liu, Hong-wei Xu, Jian Xia, Xiao-ping Du, Zhi-ping Hu
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 27 Issue 3 Pg. 316-9 (Jun 2010) ISSN: 1003-9406 [Print] China
• PMID: 20533273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tissue Kallikreins

Topics

• Adult
• Aged
• Asian People (genetics)
• Cerebral Hemorrhage (genetics)
• Female
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide (genetics)
• Tissue Kallikreins (genetics)