Abstract | BACKGROUND: METHODS: In vivo and in vitro (microperfusion) experiments were developed to investigate the effect of Carba in the rat Inner Medullary Collecting Duct (IMCD). RESULTS: The results revealed that Carba was able to stimulate the V2 vasopressin receptor- Protein G complex increasing the (Pf) and water absorption. In vivo studies showed that in rats with lithium-induced DI, Carba decreased the urinary volume and increased the urinary osmolality. AQP2 expression was increased both in normal IMCD incubated with Carba and in IMCD from lithium-induced DI after Carba addition to the diet, when compared with the control. CONCLUSION:
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Authors | Ana C de Bragança, Zenaide P Moyses, Antonio J Magaldi |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 25
Issue 12
Pg. 3840-5
(Dec 2010)
ISSN: 1460-2385 [Electronic] England |
PMID | 20525972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Aquaporin 2
- Receptors, Vasopressin
- Water
- Carbamazepine
- Lithium Chloride
|
Topics |
- Absorption
(drug effects)
- Animals
- Anticonvulsants
(adverse effects, pharmacology)
- Aquaporin 2
(metabolism)
- Carbamazepine
(adverse effects, pharmacology)
- Diabetes Insipidus
(chemically induced, metabolism)
- Disease Models, Animal
- Hyponatremia
(chemically induced, metabolism)
- Kidney Tubules, Collecting
(drug effects, metabolism)
- Lithium Chloride
(adverse effects, pharmacology)
- Male
- Rats
- Rats, Wistar
- Receptors, Vasopressin
(metabolism)
- Water
(metabolism)
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