Patterns and risk factors of helminthiasis and anemia in a rural and a peri-urban community in Zanzibar, in the context of helminth control programs.

Abstract

BACKGROUND:

The control of helminth infections and prevention of anemia in developing countries are of considerable public health importance. The purpose of this study was to determine patterns and risk factors of helminth infections and anemia in a rural and a peri-urban community of Zanzibar, Tanzania, in the context of national helminth control programs.

METHODOLOGY/PRINCIPAL FINDINGS:

We carried out a community-based cross-sectional study in 454 individuals by examining at least two stool samples with different methods for soil-transmitted helminths (Ascaris lumbricoides, hookworm, Strongyloides stercoralis, and Trichuris trichiura) and one urine sample for Schistosoma haematobium. Finger-prick blood was taken to estimate anemia levels and to detect antibody reactions against ascariasis, strongyloidiasis and schistosomiasis, using an enzyme-linked immunosorbent assay (ELISA) approach. Parasitological methods determined a helminth prevalence of 73.7% in the rural, and 48.9% in the peri-urban setting. Most helminth infections were of light intensity with school-aged children showing the highest intensities. Multiple helminth species infections were pervasive in rural dwellers regardless of age. More than half of the participants were anemic, with a particularly high prevalence in the peri-urban setting (64.7%). Risk factors for helminth infections were age, sex, consumption of raw vegetables or salad, recent travel history, and socio-economic status.

CONCLUSION/SIGNIFICANCE:

After several years of chemotherapy-based morbidity control efforts in Zanzibar, helminth prevalences are still high and anemia is common, but helminth infection intensities are low. Hence, chemotherapy should be continued, and complemented with improved access to clean water, adequate sanitation, and health education, along with poverty alleviation measures for a more enduring impact.

• Authors: Stefanie Knopp, Khalfan A Mohammed, J Russell Stothard, I Simba Khamis, David Rollinson, Hanspeter Marti, Jürg Utzinger
• Journal: PLoS neglected tropical diseases (PLoS Negl Trop Dis) Vol. 4 Issue 5 Pg. e681 (May 11 2010) ISSN: 1935-2735 [Electronic] United States
• PMID: 20485491 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Antibodies, Helminth

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Ancylostomatoidea (isolation & purification)
• Anemia (epidemiology, parasitology, prevention & control)
• Animals
• Anthelmintics (therapeutic use)
• Antibodies, Helminth (blood)
• Ascaris lumbricoides (isolation & purification)
• Child
• Child, Preschool
• Comorbidity
• Cross-Sectional Studies
• Feces (parasitology)
• Female
• Helminthiasis (complications, epidemiology, prevention & control)
• Humans
• Infant
• Infant, Newborn
• Male
• Middle Aged
• Prevalence
• Risk Factors
• Rural Population
• Schistosoma haematobium (isolation & purification)
• Strongyloides stercoralis (isolation & purification)
• Tanzania (epidemiology)
• Trichuris (isolation & purification)
• Urine (parasitology)