To investigate the efficacy of anti-tuberculous
therapy and systemic
corticosteroids in patients suffering from active presumed tuberculous
choroiditis by the assessment of central
retinal sensitivity and fixation characteristics. Six patients (six eyes) with active presumed tuberculous
choroiditis were treated with anti-tuberculous
therapy and systemic
corticosteroids. Mean central
retinal sensitivities and fixation stability and location were investigated with MP-1 microperimetry before and
after treatment. After a mean follow-up of 11.33 ± 7.53 months (range 6-24 months), all eyes showed resolution of
inflammation, with no recurrences, associated with a significant improvement in visual acuity (P = 0.003). At the baseline, mean central
retinal sensitivities were 2.03 ± 2.46 dB (range 0.0-6.6 dB). Fixation was stable and predominantly central in three eyes, and unstable and predominantly eccentric in three eyes.
After treatment at a mean of 9.33 ± 6.56 months (range 4-20 months), mean central
retinal sensitivities improved to 9.65 ± 5.35 dB (range 2.4-15.2 dB) (P = 0.004) and fixation became predominantly central and stable in all eyes. Anti-tuberculous
therapy combined with systemic
corticosteroids improves central
retinal sensitivity and fixation characteristics in patients with presumed tuberculous
choroiditis.