Abstract | BACKGROUND: METHODS: Six-day-old naïve and AD transgenic (B6.Cg-Tg[ amyloid precursor protein swe, PSEN1dE9]85Dbo/J) mice were treated with sevoflurane. The mice were killed at the end of the anesthesia, and the brain tissues were harvested and then subjected to Western blot, immunocytochemistry, enzyme-linked immunosorbent assay, and real-time polymerase chain reaction. RESULTS: CONCLUSION: These results suggest that sevoflurane may induce neurotoxicity in neonatal mice. AD transgenic mice could be more vulnerable to such neurotoxicity. These findings should promote more studies to determine the potential neurotoxicity of anesthesia in animals and humans, especially in children.
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Authors | Yan Lu, Xu Wu, Yuanlin Dong, Zhipeng Xu, Yiying Zhang, Zhongcong Xie |
Journal | Anesthesiology
(Anesthesiology)
Vol. 112
Issue 6
Pg. 1404-16
(Jun 2010)
ISSN: 1528-1175 [Electronic] United States |
PMID | 20460993
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Sevoflurane
- Caspase 3
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Topics |
- Alzheimer Disease
(genetics, pathology)
- Anesthetics, Inhalation
(toxicity)
- Animals
- Animals, Newborn
- Apoptosis
(drug effects, genetics, physiology)
- Brain
(drug effects, pathology)
- Caspase 3
(metabolism)
- Learning Disabilities
(chemically induced, prevention & control)
- Methyl Ethers
(toxicity)
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Sevoflurane
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