Abstract | BACKGROUND: STUDY DESIGN AND METHODS: This was an analytic cohort analysis of patients enrolled in a randomized controlled trial, TRIPICU (Transfusion Requirements in Pediatric Intensive Care Units; ISRCTN37246456), in which stable critically ill children were randomly assigned to a restrictive or liberal strategy. Transfused patients were analyzed using three different sliding time cutoffs (7, 14, and 21 days). Storage time for multiply transfused patients was defined according to the oldest unit transfused. RESULTS: A total of 455 patients were retained (liberal, 310; restrictive, 145). Multivariate logistic regression was performed to determine independent associations. In the restrictive group, a maximum RBC storage time of more than 21 days was independently associated with new or progressive MODS (adjusted odds ratio [OR], 3.29; 95% confidence interval [CI], 1.21-9.04). The same association was found in the liberal group for a storage time of more than 14 days (adjusted OR, 2.50; 95% CI, 1.12-5.58). When the two groups were combined in a meta-analysis, a storage time of more than 14 days was independently associated with increased MODS (adjusted OR, 2.23; 95% CI, 1.20-4.15) and more than 21 days was associated with increased Pediatric Logistic Organ Dysfunction (PELOD) scores (adjusted mean difference, 4.26; 95% CI, 1.99-6.53) and higher mortality (9.2% vs. 3.8%). CONCLUSION: Stable critically ill children who receive RBC units with storage times longer than 2 to 3 weeks may be at greater risk of developing new or progressive MODS.
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Authors | France Gauvin, Philip C Spinella, Jacques Lacroix, Ghassan Choker, Thierry Ducruet, Oliver Karam, Paul C Hébert, James S Hutchison, Heather A Hume, Marisa Tucci, Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network |
Journal | Transfusion
(Transfusion)
Vol. 50
Issue 9
Pg. 1902-13
(Sep 2010)
ISSN: 1537-2995 [Electronic] United States |
PMID | 20456697
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 American Association of Blood Banks. |
Topics |
- Adolescent
- Blood Preservation
(adverse effects)
- Child
- Child, Preschool
- Erythrocyte Transfusion
(adverse effects)
- Female
- Humans
- Infant
- Infant, Newborn
- Intensive Care Units, Pediatric
- Male
- Multiple Organ Failure
(etiology)
- Time Factors
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