High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L.

Abstract

Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500 mg kg(-1) d(-1), 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease.

• Authors: Pierre Watcho, Roman Stavniichuk, David M Ribnicky, Ilya Raskin, Irina G Obrosova
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2010 Pg. 268547 ( 2010) ISSN: 1466-1861 [Electronic] United States
• PMID: 20396384 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Dietary Fats
• PMI-5011
• Plant Extracts

Topics

• Animals
• Artemisia (chemistry)
• Behavior, Animal (physiology)
• Blood Glucose (metabolism)
• Diabetic Neuropathies (drug therapy, pathology)
• Dietary Fats
• Humans
• Male
• Mice
• Mice, Inbred C57BL
• Obesity (complications, drug therapy)
• Pain Measurement
• Plant Extracts (therapeutic use)
• Prediabetic State (complications, drug therapy)