Abstract | AIM: To compare levels of lipid peroxidation and antioxidants in synovial fluid from primary knee osteoarthritis (OA) patients with severe cartilage damage undergoing total knee replacement with those in the synovial fluid from injured knee joint patients with intact cartilage undergoing knee arthroscopy. METHODS: RESULTS:
TBARs, iron and GSH levels in synovial fluid were not significantly different between OA patients and injured knee joint patients. Antioxidant enzymes such as GPx and SOD activities also indicated no significant difference. Only vitamin E level was significantly lower in the synovial fluid of OA patients than in that of the injured knee joint patients. CONCLUSIONS: Oxidative stress may have a role in pathogenesis of knee osteoarthritis. Vitamin E supplementation may have a role in the management of patients.
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Authors | Werasak Sutipornpalangkul, Noppawan P Morales, Keerati Charoencholvanich, Thossart Harnroongroj |
Journal | International journal of rheumatic diseases
(Int J Rheum Dis)
Vol. 12
Issue 4
Pg. 324-8
(Dec 2009)
ISSN: 1756-185X [Electronic] England |
PMID | 20374370
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Biomarkers
- Iron Compounds
- Thiobarbituric Acid Reactive Substances
- Vitamin E
- Oxidoreductases
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antioxidants
(metabolism)
- Biomarkers
(metabolism)
- Chromatography, High Pressure Liquid
- Glutathione
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Humans
- Iron Compounds
(metabolism)
- Knee Injuries
(metabolism, pathology, surgery)
- Lipid Peroxidation
- Middle Aged
- Osteoarthritis, Knee
(metabolism, pathology, surgery)
- Oxidoreductases
(metabolism)
- Superoxide Dismutase
(metabolism)
- Synovial Fluid
(metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Vitamin E
(metabolism)
- Young Adult
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