Thiopental improves renal ischemia-reperfusion injury.

Abstract

UNLABELLED:

Ischemia/reperfusion (I/R) occurs in a number of pathological conditions, including myocardial infarction, stroke, aortic surgery, cardiopulmonary bypass surgery, organ transplantation, resuscitation, and critical care. Massive and abrupt release of oxygen-free radicals after reperfusion triggers oxidative damage. Before critical operations or after resuscitation, it would be wise to find a suitable prophylactic treatment to avoid I/R damage. We aimed to determine whether several commonly used intravenous anesthetics protect against renal I/R injury.

METHODS:

Animals were randomly divided into seven groups, each consisting of six animals: sham group, control group, thiopental group, propofol group, intralipid group, etomidate group, and ketamine group. At the end of the 60-min ischemic period, 60 min reperfusion was established and the materials administered 15 min before the reperfusion. At the end of the reperfusion period, the samples of blood and tissue were reaped for biochemical and serological evaluation.

RESULTS:

I/R procedure significantly increased malondialdehyde (MDA) levels, decreased catalase (CAT) activities, and superoxide dismutase (SOD) levels. The lowest MDA mean level was in the thiopental group and the highest MDA mean level was in control group. The lowest CAT mean level was in the intralipid group and the highest CAT mean level was in the etomidate group. The lowest SOD mean level was in the control group and the highest SOD mean level was in the propofol group.

CONCLUSION:

Thiopental and propofol, especially thiopental, are more effective to protect renal I/R injury.

• Authors: Zafer Dogan, Mehmet Fatih Yuzbasioglu, Ergul Belge Kurutas, Huseyin Yildiz, Ismail Coskuner, Nimet Senoglu, Hafize Oksuz, Ertan Bülbüloglu
• Journal: Renal failure (Ren Fail) Vol. 32 Issue 3 Pg. 391-5 (Jan 2010) ISSN: 1525-6049 [Electronic] England
• PMID: 20370458 (Publication Type: Journal Article)

Chemical References

• Anesthetics, Dissociative
• Anesthetics, Intravenous
• Antioxidants
• Fat Emulsions, Intravenous
• Malondialdehyde
• Ketamine
• Catalase
• Superoxide Dismutase
• Thiopental
• Propofol
• Etomidate

Topics

• Anesthetics, Dissociative (pharmacology)
• Anesthetics, Intravenous (pharmacology)
• Animals
• Antioxidants (metabolism, pharmacology)
• Catalase (metabolism)
• Etomidate (pharmacology)
• Fat Emulsions, Intravenous (pharmacology)
• Ketamine (pharmacology)
• Kidney (blood supply, metabolism)
• Lipid Peroxidation (drug effects)
• Malondialdehyde (metabolism)
• Propofol (pharmacology)
• Rats
• Rats, Wistar
• Reperfusion Injury (metabolism, prevention & control)
• Superoxide Dismutase (metabolism)
• Thiopental (pharmacology)