Interleukin-18 in intestinal inflammation: friend and foe?

Abstract	Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells.
Authors	Britta Siegmund
Journal	Immunity (Immunity) Vol. 32 Issue 3 Pg. 300-2 (Mar 26 2010) ISSN: 1097-4180 [Electronic] United States
PMID	20346770 (Publication Type: Journal Article, Comment)
Chemical References	Carrier Proteins Interleukin-18 NLR Family, Pyrin Domain-Containing 3 Protein Nlrp3 protein, mouse Caspase 12 Caspase 1
Topics	Animals Carrier Proteins (genetics, immunology) Caspase 1 (deficiency, immunology, metabolism) Caspase 12 (deficiency, immunology, metabolism) Colitis (enzymology, genetics, immunology, pathology) Epithelial Cells (cytology, immunology) Humans Interleukin-18 (biosynthesis, immunology) Mice NLR Family, Pyrin Domain-Containing 3 Protein

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!