Abstract | INTRODUCTION: AIM: The primary objective was to assess the effect on ejaculatory dysfunction (EjD) of 6 months treatment with alfuzosin ( XATRAL) 10 mg once daily (OD) in men with LUTS suggestive of BPH in Thailand. Secondary objectives were to evaluate the efficacy of alfuzosin on LUTS, bother score (International Prostate Symptom Score [IPSS] 8th question), erectile dysfunction (ED), onset of action, and tolerability. METHODS: Overall, 99 men with moderate to severe LUTS suggestive of BPH (mean IPSS 18.9, bother score 4.3) were enrolled in an open-label study. Sexual function was evaluated at baseline and after 6 months treatment, using the International Index of Erectile Function-5 and the Male Sexual Health Questionnaire (MSHQ) ejaculation score, a new validated questionnaire assessing seven EjD symptoms. MAIN OUTCOME MEASURE: The main outcome measure is mean change from baseline to the end of treatment in the MSHQ Ejaculation score. RESULTS: MHSQ ejaculation score significantly improved from 23.09 at baseline to 21.54 at 6 months (P=0.022). Overall, 70% of patients perceived an improvement in LUTS within 1 week (36.3% within 3 days). IPSS total score significantly improved from 18.93 at baseline to 9.59 at 6 months (P<0.001). IPSS voiding and irritative subscores also significantly improved. The percentage of patients with moderate or severe ED decreased from 35.3% at baseline to 21.8% at 6 months. Most adverse events were dizziness (3%) and orthostatic hypotension (1%) with minor intensity. No significant change in blood pressure and heart rate was observed. CONCLUSIONS:
Alfuzosin 10 mg OD administered for 6 months provides a marked and rapid (within 1 week) improvement in LUTS and bother score while improving both ED and EjD.
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Authors | Somboon Leungwattanakij, Damrongpun Watanachote, Patra Noppakulsatit, T Petchpaibuol, Nopporn Choeypunt, Thanasak Tongbai, Teerawan Wanamkang, Bunnakij Lojanapiwat, Sompol Permpongkosol, Anupan Tantiwong, Chusak Pripatnanont, Danaipan Akarasakul, Somsak Kongwiwatanakul, Ekarat Chotikawanich |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 7
Issue 9
Pg. 3115-26
(Sep 2010)
ISSN: 1743-6109 [Electronic] Netherlands |
PMID | 20233288
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 International Society for Sexual Medicine. |
Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Quinazolines
- alfuzosin
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
(therapeutic use)
- Aged
- Ejaculation
(drug effects)
- Erectile Dysfunction
(drug therapy, etiology)
- Humans
- Male
- Middle Aged
- Nocturia
(drug therapy)
- Prostatic Hyperplasia
(complications, drug therapy)
- Quinazolines
(therapeutic use)
- Severity of Illness Index
- Thailand
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