In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes.

Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24 h in MCF-7 and U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled PolyDOC t(1/2) and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.
AuthorsKamal K Upadhyay, Anant N Bhatt, Emilio Castro, Anil K Mishra, Krishna Chuttani, Bilikere S Dwarakanath, Christophe Schatz, Jean-François Le Meins, Ambikanandan Misra, Sébastien Lecommandoux
JournalMacromolecular bioscience (Macromol Biosci) Vol. 10 Issue 5 Pg. 503-12 (May 14 2010) ISSN: 1616-5195 [Electronic] Germany
PMID20232310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Capsules
  • Delayed-Action Preparations
  • Taxoids
  • poly(gamma-benzyl glutamate)-b-hyaluronan
  • docetaxel
  • Polyglutamic Acid
  • Hyaluronic Acid
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacokinetics)
  • Capsules
  • Cell Line, Tumor
  • Delayed-Action Preparations (chemistry)
  • Female
  • Humans
  • Hyaluronic Acid (analogs & derivatives, chemistry)
  • Mice
  • Mice, Inbred BALB C
  • Polyglutamic Acid (analogs & derivatives, chemistry)
  • Rabbits
  • Taxoids (administration & dosage, pharmacokinetics)

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