HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes.

Abstract
Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24 h in MCF-7 and U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled PolyDOC t(1/2) and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.
AuthorsKamal K Upadhyay, Anant N Bhatt, Emilio Castro, Anil K Mishra, Krishna Chuttani, Bilikere S Dwarakanath, Christophe Schatz, Jean-François Le Meins, Ambikanandan Misra, Sébastien Lecommandoux
JournalMacromolecular bioscience (Macromol Biosci) Vol. 10 Issue 5 Pg. 503-12 (May 14 2010) ISSN: 1616-5195 [Electronic] Germany
PMID20232310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Capsules
  • Delayed-Action Preparations
  • Taxoids
  • poly(gamma-benzyl glutamate)-b-hyaluronan
  • docetaxel
  • Polyglutamic Acid
  • Hyaluronic Acid
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacokinetics)
  • Capsules
  • Cell Line, Tumor
  • Delayed-Action Preparations (chemistry)
  • Female
  • Humans
  • Hyaluronic Acid (analogs & derivatives, chemistry)
  • Mice
  • Mice, Inbred BALB C
  • Polyglutamic Acid (analogs & derivatives, chemistry)
  • Rabbits
  • Taxoids (administration & dosage, pharmacokinetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: